期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 294, 期 14, 页码 5408-5419出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.TM118.000831
关键词
induced pluripotent stem cell (iPS cell) (iPSC); pluripotency; histone demethylase; DNA demethylation; stem cells; epigenetics; chromatin; reprogramming; cell differentiation; alpha-KG enzymes; cell fate
资金
- Shaw Scientist Award
- National Institutes of Health [RO1GM113033]
- National Institute of General Medical Sciences, National Institutes of Health [T32GM081061]
- Advanced Opportunity Fellowship at the University of Wisconsin-Madison
- National Science Foundation Graduate Research Fellowship Program [DGE-1256259]
alpha-Ketoglutarate is an important metabolic intermediate that acts as a cofactor for several chromatin-modifying enzymes, including histone demethylases and the Tet family of enzymes that are involved in DNA demethylation. In this review, we focus on the function and genomic localization of these -ketoglutarate-dependent enzymes in the maintenance of pluripotency during cellular reprogramming to induced pluripotent stem cells and in disruption of pluripotency during in vitro differentiation. The enzymatic function of many of these -ketoglutarate-dependent proteins is required for pluripotency acquisition and maintenance. A better understanding of their specific function will be essential in furthering our knowledge of pluripotency.
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