期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 289, 期 50, 页码 34466-34471出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R114.591560
关键词
Diabetes; Insulin Resistance; O-GlcNAcylation; O-linked N-Acetylglucosamine (O-GlcNAc); Type 2 Diabetes; OGA; OGT; Hexosamine Biosynthetic Pathway
资金
- National Institutes of Health through the NIGMS [P41GM103490, P01GM107012]
In this minireview, we will highlight work in the last 30 years that has clearly demonstrated that the O-GlcNAc modification is nutrient-responsive and plays multiple roles in metabolic regulation of signaling and gene expression. Further, we will examine recent studies that have investigated the impact of O-GlcNAc in a variety of glucose- and insulin-responsive tissues and the roles attributed to O-GlcNAc in the induction of insulin resistance and glucose toxicity, the hallmarks of type II diabetes mellitus. We will also summarize potential causal roles for the O-GlcNAc modification in complications associated with diabetes.
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