期刊
ANTIOXIDANTS & REDOX SIGNALING
卷 22, 期 12, 页码 1020-1031出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2014.6208
关键词
-
资金
- MINECO [SAF2008-03803]
- Generalitat de Catalunya [2009SGR915]
- CIBERDEM (Instituto de Salud Carlos III)
- INTERREG IV-B-SUDOE-FEDER (DIOMED) [SOE1/P1/E178]
Significance: Mitochondrial dynamics is a complex process that impacts on mitochondrial biology. Recent Advances: Recent evidence indicates that proteins participating in mitochondrial dynamics have additional cellular roles. Mitofusin 2 (Mfn2) is a potent modulator of mitochondrial metabolism with an impact on energy metabolism in muscle, liver, and hypothalamic neurons. In addition, Mfn2 is subjected to tight regulation. Hence, factors such as proinflammatory cytokines, lipid availability, or glucocorticoids block its expression, whereas exercise and increased energy expenditure promote its upregulation. Critical Issues: Importantly, Mfn2 controls cell metabolism and insulin signaling by limiting reactive oxygen species production and by modulation of endoplasmic reticulum stress. In this connection, it is critical to understand precisely the molecular mechanisms involved in the global actions of Mfn2. Future Directions: Future directions should concentrate into the analysis of those mechanisms, and to fully demonstrate that Mfn2 represents a cellular hub that senses the metabolic and hormonal milieu and drives the control of metabolic homeostasis. Antioxid. Redox Signal. 22, 1020-1031.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据