期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 289, 期 33, 页码 22630-22635出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M114.569459
关键词
-
资金
- Beijing Scientific Foundation [131107002213040]
The immune regulatory functions of B cells are not fully understood yet. The present study aims to characterize a sub-type of B cells that expresses CX3CR1. In this study, peripheral blood samples were collected from patients with food allergies and healthy subjects. Peripheral B cells were analyzed by flow cytometry. T cell proliferation was assessed by carboxyfluorescein succinimidyl ester dilution assay. The results showed that the CX3CR1(+) B cells were detected in the peripheral blood samples of healthy subjects and were significantly less in patients with food allergies. CX3CR1(+) B cells expressed high levels of TGF-beta and integrin alpha v beta 6. CX3CR1(+) B cells could efficiently suppress other effector CD4(+) T cell activation. We conclude that human peripheral CX3CR1(+) B cells have immune suppressor properties.
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