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X. Wang et al.
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Rachel Litman Flynn et al.
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Cynthia X. Ma et al.
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Atsushi Shibata et al.
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Yuji Nakayama et al.
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Izumi Sato et al.
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Elizabeth M. Kass et al.
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Ivan Mamely et al.
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Van Leung-Pineda et al.
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Dong Zhang et al.
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Niels Mailand et al.
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SCFβTrCP-mediated degradation of claspin regulates recovery from the DNA replication checkpoint response
Angelo Peschiaroli et al.
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Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress
Xin Wang et al.
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Lyubomir T. Vassilev et al.
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KE Adams et al.
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JS Myers et al.
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ATM regulates ATR chromatin loading in response to DNA double-strand breaks
M Cuadrado et al.
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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
A Jazayeri et al.
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Genotoxic stress targets human Chk1 for degradation by the ubipuitin-proteasome pathway
YW Zhang et al.
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PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints
XB Lu et al.
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Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage
RG Syljuåsen et al.
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Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
TS Byun et al.
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Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles
KL Arienti et al.
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ZW He et al.
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Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation
Y Katsuragi et al.
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Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains
CP Ng et al.
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BBS Zhou et al.
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Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1
NR den Elzen et al.
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MATM van Vugt et al.
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C Latif et al.
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K Kasahara et al.
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S Shangary et al.
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Y Ishimi et al.
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Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation
M Gatei et al.
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B Xu et al.
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IM Ward et al.
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S Post et al.
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H Ohnishi et al.
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AV Grishin et al.
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SD Bao et al.
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RA Blake et al.
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