期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 288, 期 11, 页码 7430-7437出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R112.444158
关键词
-
资金
- National Institutes of Health from NCI [CA61986]
- BBSRC [BB/I014276/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/I014276/1] Funding Source: researchfish
The discoidin domain receptors (DDRs) are receptor tyrosine kinases that recognize collagens as their ligands. DDRs display unique structural features and distinctive activation kinetics, which set them apart from other members of the kinase superfamily. DDRs regulate cell-collagen interactions in normal and pathological conditions and thus are emerging as major sensors of collagen matrices and potential novel therapeutic targets. New structural and biological information has shed light on the molecular mechanisms that regulate DDR signaling, turnover, and function. This minireview provides an overview of these areas of DDR research with the goal of fostering further investigation of these intriguing and unique receptors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据