4.6 Article

γ-Secretase Modulator (GSM) Photoaffinity Probes Reveal Distinct Allosteric Binding Sites on Presenilin

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

BMS-708,163 Targets Presenilin and Lacks Notch-Sparing Activity

Christina J. Crump et al.

BIOCHEMISTRY (2012)

Article Chemistry, Medicinal

Development of clickable active site-directed photoaffinity probes for γ-secretase

Christina J. Crump et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)

Article Biochemistry & Molecular Biology

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

Lucia Chavez-Gutierrez et al.

EMBO JOURNAL (2012)

Article Biochemistry & Molecular Biology

Familial Alzheimer Disease Presenilin-1 Mutations Alter the Active Site Conformation of γ-secretase

De-Ming Chau et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

First and Second Generation γ-Secretase Modulators (GSMs) Modulate Amyloid-β (Aβ) Peptide Production through Different Mechanisms

Tomas Borgegard et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Multidisciplinary Sciences

Presenilin Is the Molecular Target of Acidic γ-Secretase Modulators in Living Cells

Thorsten Jumpertz et al.

PLOS ONE (2012)

Article Medicine, Research & Experimental

Presenilins and γ-Secretase: Structure, Function, and Role in Alzheimer Disease

Bart De Strooper et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

Article Biochemistry & Molecular Biology

Piperidine Acetic Acid Based γ-Secretase Modulators Directly Bind to Presenilin-1

Christina J. Crump et al.

ACS CHEMICAL NEUROSCIENCE (2011)

Article Biochemistry & Molecular Biology

NSAID-Based γ-Secretase Modulators Do Not Bind to the Amyloid-β Polypeptide

Paul J. Barrett et al.

BIOCHEMISTRY (2011)

Article Chemistry, Multidisciplinary

Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe

Haibin Shi et al.

CHEMICAL COMMUNICATIONS (2011)

Article Biochemistry & Molecular Biology

Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1

Yu Ohki et al.

EMBO JOURNAL (2011)

Review Chemistry, Medicinal

Novel γ-secretase modulators: a review of patents from 2008 to 2010

Martin Pettersson et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2011)

Article Biochemistry & Molecular Biology

Novel γ-Secretase Enzyme Modulators Directly Target Presenilin Protein

Amelie Ebke et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Substrate Sequence Influences γ-Secretase Modulator Activity, Role of the Transmembrane Domain of the Amyloid Precursor Protein

Sarah A. Sagi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Chemistry, Medicinal

γ-Secretase Modulators as Potential Disease Modifying Anti-Alzheimer's Drugs

Daniel Oehlrich et al.

JOURNAL OF MEDICINAL CHEMISTRY (2011)

Article Chemistry, Multidisciplinary

Unraveling the Protein Targets of Vancomycin in Living S. aureus and E. faecalis Cells

Juergen Eirich et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

Review Biotechnology & Applied Microbiology

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

Eric Karran et al.

NATURE REVIEWS DRUG DISCOVERY (2011)

Review Clinical Neurology

The secretases: enzymes with therapeutic potential in Alzheimer disease

Bart De Strooper et al.

NATURE REVIEWS NEUROLOGY (2010)

Article Multidisciplinary Sciences

Activation and intrinsic γ-secretase activity of presenilin 1

Kwangwook Ahn et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Pharmacology & Pharmacy

Exploring the chemical space of gamma-secretase modulators

Heiko Zettl et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2010)

Article Chemistry, Medicinal

Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor

Kevin W. Gillman et al.

ACS MEDICINAL CHEMISTRY LETTERS (2010)

Article Multidisciplinary Sciences

Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site

Kengo Uemura et al.

NATURE COMMUNICATIONS (2010)

Review Biochemistry & Molecular Biology

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

Raphael Kopan et al.

Article Chemistry, Medicinal

Promiscuous Aggregate-Based Inhibitors Promote Enzyme Unfolding

Kristin E. D. Coan et al.

JOURNAL OF MEDICINAL CHEMISTRY (2009)

Review Biochemistry & Molecular Biology

Amyloid Precursor Protein Trafficking, Processing, and Function

Gopal Thinakaran et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Chemistry, Multidisciplinary

Optimization of activity-based probes for proteomic profiling of histone deacetylase complexes

Cleo M. Salisbury et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

Article Multidisciplinary Sciences

Substrate-targeting γ-secretase modulators

Thomas L. Kukar et al.

NATURE (2008)

Article Chemistry, Multidisciplinary

Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation

Andrew L. MacKinnon et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

Article Biochemistry & Molecular Biology

Humoral immune responses to peptides derived from the β-amyloid peptide C-terminal sequence

David L. Miller et al.

AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2007)

Article Multidisciplinary Sciences

The initial substrate-binding site of γ-secretase is located on presenilin near the active site

AY Kornilova et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Profiling enzyme activities in vivo using click chemistry methods

AE Speers et al.

CHEMISTRY & BIOLOGY (2004)

Article Chemistry, Medicinal

A specific mechanism of nonspecific inhibition

SL McGovern et al.

JOURNAL OF MEDICINAL CHEMISTRY (2003)

Article Medicine, Research & Experimental

NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo

JL Eriksen et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)

Article Biochemistry & Molecular Biology

Sulindac sulfide is a noncompetitive γ-secretase inhibitor that preferentially reduces Aβ42 generation

Y Takahashi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Multidisciplinary Sciences

Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state

YM Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)