Structural Basis for Selective Vascular Endothelial Growth Factor-A (VEGF-A) Binding to Neuropilin-1

Background: Neuropilin is an essential cell surface receptor for VEGF-A in angiogenesis. Results: VEGF-A(164) uniquely physically engages neuropilin using two distinct regions. Conclusion: These data establish the structural basis for selective VEGF-A splice form binding to neuropilin. Significance: Understanding VEGF receptor binding will advance therapeutic targeting of pathological angiogenesis.