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BIOCHEMICAL JOURNAL (2012)
Acyl Chain Specificity of Ceramide Synthases Is Determined within a Region of 150 Residues in the Tram-Lag-CLN8 (TLC) Domain
Rotem Tidhar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics
Alfred H. Merrill
CHEMICAL REVIEWS (2011)
Encephalopathy Caused by Ablation of Very Long Acyl Chain Ceramide Synthesis May Be Largely Due to Reduced Galactosylceramide Levels
Oshrit Ben-David et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Ceramide Synthase-dependent Ceramide Generation and Programmed Cell Death INVOLVEMENT OF SALVAGE PATHWAY IN REGULATING POSTMITOCHONDRIAL EVENTS
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JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism
Thomas D. Mullen et al.
JOURNAL OF LIPID RESEARCH (2011)
A Deficiency of Ceramide Biosynthesis Causes Cerebellar Purkinje Cell Neurodegeneration and Lipofuscin Accumulation
Lihong Zhao et al.
PLOS GENETICS (2011)
Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells
Judith Mesicek et al.
CELLULAR SIGNALLING (2010)
A Critical Role for Ceramide Synthase 2 in Liver Homeostasis I. ALTERATIONS IN LIPID METABOLIC PATHWAYS
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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Curcumin-Induced Apoptosis in PC3 Prostate Carcinoma Cells Is Caspase-Independent and Involves Cellular Ceramide Accumulation and Damage to Mitochondria
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NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2010)
Ceramide synthase 1 is regulated by proteasomal mediated turnover
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2009)
Ceramide Synthesis Is Modulated by the Sphingosine Analog FTY720 via a Mixture of Uncompetitive and Noncompetitive Inhibition in an Acyl-CoA Chain Length-dependent Manner
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JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers
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JOURNAL OF LIPID RESEARCH (2009)
De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation
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PROSTAGLANDINS & OTHER LIPID MEDIATORS (2008)
Characterization of ceramide synthase 2 - Tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Kinetic characterization of mammalian ceramide synthases:: Determination of Km values towards sphinganine
Sujoy Lahiri et al.
FEBS LETTERS (2007)
New functional motif in Hox domain-containing ceramide Synthases - Identification of a novel region flanking the Hox and TLC domains essential for activity
Adi Mesika et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
A molecular caliper mechanism for determining very long-chain fatty acid length
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CELL (2007)
The metabolism and function of sphingolipids and glycosphingolipids
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CELLULAR AND MOLECULAR LIFE SCIENCES (2007)
Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity
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BIOCHEMICAL JOURNAL (2006)
Transmembrane topology of ceramide synthase in yeast
Natsuko Kageyama-Yahara et al.
BIOCHEMICAL JOURNAL (2006)
Curcumin mediates ceramide generation via the de novo pathway in colon cancer cells
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CARCINOGENESIS (2006)
RF cloning:: A restriction-free method for inserting target genes into plasmids
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JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS (2006)
When do lasses (longevity assurance genes) become CerS (ceramide synthases)? Insights into the regulation of ceramide synthesis
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor
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JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Mammalian Lass6 and its related family members regulate synthesis of specific ceramides
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BIOCHEMICAL JOURNAL (2005)
Sphingolipidomics: High-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry
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METHODS (2005)
Lip1p:: a novel subunit of acyl-CoA ceramide synthase
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EMBO JOURNAL (2005)
Ceramide synthase is essential for endonuclease-mediated death of renal tubular epithelial cells induced by hypoxia-reoxygenation
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AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2005)
Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism
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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2003)
Acute activation of de novo sphingolipid biosynthesis upon heat shock causes an accumulation of ceramide and subsequent dephosphorylation of SR proteins
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Two histidine residues are essential for catalysis by lecithin retinol acyl transferase
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FEBS LETTERS (2001)
De novo-synthesized ceramide signals apoptosis in astrocytes via extracellular signal-regulated kinase
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FASEB JOURNAL (2000)