期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 287, 期 51, 页码 42444-42452出版社
ELSEVIER
DOI: 10.1074/jbc.R112.402768
关键词
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资金
- National Institutes of Health [AG032375, DK088190, GM093072, T32 DK007260]
- Beatriu de Pinos postdoctoral fellowship
- Paul F. Glenn Foundation for Medical Research
Originally rising to notoriety for their role in the regulation of aging, sirtuins are a family of NAD(+)-dependent enzymes that have been connected to a steadily growing set of biological processes. In addition to regulating aging, sirtuins play key roles in the maintenance of organismal metabolic homeostasis. These enzymes also have primarily protective functions in the development of many age-related diseases, including cancer, neurodegeneration, and cardiovascular disease. In this minireview, we provide an update on the known roles for each of the seven mammalian sirtuins in these areas.
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