期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 287, 期 49, 页码 40875-40883出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R112.416925
关键词
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资金
- National Institutes of Health [R01 AI064046, P01 GM091743, R01 AI098485, R21 AI087498, P51 RR000168/OD011103]
- University of Minnesota
Cellular proteins called restriction factors can serve as powerful blockades to HIV replication, but the virus possesses elaborate strategies to circumvent these barriers. First, we discuss general hallmarks of a restriction factor. Second, we review how the viral Vif protein protects the viral genome from lethal levels of cDNA deamination by promoting APOBEC3 protein degradation; how the viral Vpu, Env, and Nef proteins facilitate internalization and degradation of the virus-tethering protein BST-2/tetherin; and how the viral Vpx protein prevents the premature termination of reverse transcription by degrading the dNTPase SAMHD1. These HIV restriction and counter-restriction mechanisms suggest strategies for new therapeutic interventions.
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