期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 287, 期 27, 页码 22781-22788出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M112.356337
关键词
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资金
- Medical Research Council
- European Research Council
- Biotechnology and Biological Sciences Research Council
- Wellcome Trust
- Marie Curie fellowship
- European Molecular Biology Organization short-term fellowship
- Medical Research Council [G0601810] Funding Source: researchfish
- MRC [G0601810] Funding Source: UKRI
Homeostatic scaling allows neurons to alter synaptic transmission to compensate for changes in network activity. Here, we show that suppression of network activity with tetrodotoxin, which increases surface expression of AMPA receptors (AMPARs), dramatically reduces levels of the deSUMOylating (where SUMO is small ubiquitin-like modifier) enzyme SENP1, leading to a consequent increase in protein SUMOylation. Overexpression of the catalytic domain of SENP1 prevents this scaling effect, and we identify Arc as a SUMO substrate involved in the tetrodotoxin-induced increase in AMPAR surface expression. Thus, protein SUMOylation plays an important and previously unsuspected role in synaptic trafficking of AMPARs that underlies homeostatic scaling.
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