期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 287, 期 16, 页码 13348-13355出版社
ELSEVIER
DOI: 10.1074/jbc.M111.331330
关键词
-
资金
- Canadian Institute for Health Research
- Canadian Foundation of Innovation
- British Columbia Knowledge Development Fund
- Natural Sciences and Engineering Research Council of Canada
SopB is a type III secreted Salmonella effector protein with phosphoinositide phosphatase activity and a distinct GTPase binding domain. The latter interacts with host Cdc42, an essential Rho GTPase that regulates critical events in eukaryotic cytoskeleton organization and membrane trafficking. Structural and biochemical analysis of the SopB GTPase binding domain in complex with Cdc42 shows for the first time that SopB structurally and functionally mimics a host guanine nucleotide dissociation inhibitor (GDI) by contacting key residues in the regulatory switch regions of Cdc42 and slowing Cdc42 nucleotide exchange.
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