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Chi-chung Hui et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 (2011)
Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube
Miquel Tuson et al.
DEVELOPMENT (2011)
The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation
Qing Shi et al.
DEVELOPMENT (2011)
Boc and Gas1 Each Form Distinct Shh Receptor Complexes with Ptch1 and Are Required for Shh-Mediated Cell Proliferation
Luisa Izzi et al.
DEVELOPMENTAL CELL (2011)
Overlapping Roles and Collective Requirement for the Coreceptors GAS1, CDO, and BOC in SHH Pathway Function
Benjamin L. Allen et al.
DEVELOPMENTAL CELL (2011)
Sonic Hedgehog Shedding Results in Functional Activation of the Solubilized Protein
Stefanie Ohlig et al.
DEVELOPMENTAL CELL (2011)
Dual Phosphorylation of Suppressor of Fused (Sufu) by PKA and GSK3β Regulates Its Stability and Localization in the Primary Cilium
Yan Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
A Three-part Signal Governs Differential Processing of Gli1 and Gli3 Proteins by the Proteasome
Erin K. Schrader et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Processing and turnover of the Hedgehog protein in the endoplasmic reticulum
Xin Chen et al.
JOURNAL OF CELL BIOLOGY (2011)
Complex interactions between genes controlling trafficking in primary cilia
Polloneal Jymmiel R. Ocbina et al.
NATURE GENETICS (2011)
Mechanisms and functions of Hedgehog signalling across the metazoa
Philip W. Ingham et al.
NATURE REVIEWS GENETICS (2011)
Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium
Ainhoa Callejo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Sequential Phosphorylation of Smoothened Transduces Graded Hedgehog Signaling
Ying Su et al.
SCIENCE SIGNALING (2011)
Sonic Hedgehog Dependent Phosphorylation by CK1α and GRK2 Is Required for Ciliary Accumulation and Activation of Smoothened
Yongbin Chen et al.
PLOS BIOLOGY (2011)
Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors
Chengbing Wang et al.
DEVELOPMENT (2010)
Mechanism and evolution of cytosolic Hedgehog signal transduction
Christopher W. Wilson et al.
DEVELOPMENT (2010)
Role of Lipid Metabolism in Smoothened Derepression in Hedgehog Signaling
Amir Yavan et al.
DEVELOPMENTAL CELL (2010)
The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins
Eric W. Humke et al.
GENES & DEVELOPMENT (2010)
Genetic and biochemical definition of the Hedgehog receptor
Xiaoyan Zheng et al.
GENES & DEVELOPMENT (2010)
Interactions between Hedgehog proteins and their binding partners come into view
Philip A. Beachy et al.
GENES & DEVELOPMENT (2010)
G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila
Yongbin Chen et al.
GENES & DEVELOPMENT (2010)
The Full-length Unprocessed Hedgehog Protein Is an Active Signaling Molecule
Robert Tokhunts et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes
Hanna Tukachinsky et al.
JOURNAL OF CELL BIOLOGY (2010)
Histone deacetylase and Cullin3-RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation
Gianluca Canettieri et al.
NATURE CELL BIOLOGY (2010)
The primary cilium: a signalling centre during vertebrate development
Sarah C. Goetz et al.
NATURE REVIEWS GENETICS (2010)
Coordinated Translocation of Mammalian Gli Proteins and Suppressor of Fused to the Primary Cilium
Huiqing Zeng et al.
PLOS ONE (2010)
Sufu recruits GSK3β for efficient processing of Gli3
Yoshiaki Kise et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
The Mammalian Cos2 Homolog Kif7 Plays an Essential Role in Modulating Hh Signal Transduction during Development
Setsu Endoh-Yamagami et al.
CURRENT BIOLOGY (2009)
Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development
Yong Pan et al.
DEVELOPMENTAL BIOLOGY (2009)
Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia
Jinping Jia et al.
DEVELOPMENTAL BIOLOGY (2009)
Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved
Miao-Hsueh Chen et al.
GENES & DEVELOPMENT (2009)
Heparan Sulfate and Transglutaminase Activity Are Required for the Formation of Covalently Cross-linked Hedgehog Oligomers
Tabea Dierker et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Heparan Sulfate-modulated, Metalloprotease-mediated Sonic Hedgehog Release from Producing Cells
Tabea Dierker et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium
Ljiljana Milenkovic et al.
JOURNAL OF CELL BIOLOGY (2009)
Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP
Benjamin Bishop et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling
Ivan Bosanac et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling
Karel F. Liem et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus
Jynho Kim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase
Qing Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
The Kinesin Protein Kif7 Is a Critical Regulator of Gli Transcription Factors in Mammalian Hedgehog Signaling
Helen Oi-Lam Cheung et al.
SCIENCE SIGNALING (2009)
Nanoscale organization of Hedgehog is essential for long-range signaling
Neha Vyas et al.
CELL (2008)
Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog
John A. Buglino et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla
Jason S. McLellan et al.
NATURE (2008)
β-arrestin-mediated localization of smoothened to the primary cilium
Jeffrey J. Kovacs et al.
SCIENCE (2008)
Patched1 regulates Hedgehog signaling at the primary cilium
Rajat Rohatgi et al.
SCIENCE (2007)
Lipoprotein-heparan sulfate interactions in the Hh pathway
Christina Eugster et al.
DEVELOPMENTAL CELL (2007)
Region-specific requirement for cholesterol modification of sonic hedgehog in patterning the telencephalon and spinal cord
Xi Huang et al.
DEVELOPMENT (2007)
The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila
Cristina Molnar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome
Yong Pan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
A conserved mechanism of Hedgehog gradient formation by lipid modif ications
Isabel Guerrero et al.
TRENDS IN CELL BIOLOGY (2007)
GSK-3β-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome
Katsumi Fumoto et al.
EMBO JOURNAL (2006)
Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2
Alison R. Meloni et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Gli2 is targeted for ubiquitination and degradation by β-TrCP ubiquitin ligase
Neehar Bhatia et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor
Qing Zhang et al.
DEVELOPMENTAL CELL (2006)
Multisite protein kinase A and glycogen synthase kinase 3β phosphorylation leads to Gli3 ubiquitination by SCFβTrCP
Denis Tempe et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation
Y Pan et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Cholesterol modification restricts the spread of Shh gradient in the limb bud
YN Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix
A Callejo et al.
DEVELOPMENT (2006)
Genetic elimination of suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway
J Svärd et al.
DEVELOPMENTAL CELL (2006)
Evidence for the direct involvement of βTrCP in Gli3 protein processing
BW Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly
T Maity et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused
AF Cooper et al.
DEVELOPMENT (2005)
Differential range and activity of various forms of the Hedgehog protein
RJ Dawber et al.
BMC DEVELOPMENTAL BIOLOGY (2005)
Lipoprotein particles are required for Hedgehog and Wingless signalling
D Panáková et al.
NATURE (2005)
A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo
SY Tay et al.
DEVELOPMENT (2005)
Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction
S Apionishev et al.
NATURE CELL BIOLOGY (2005)
Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates
MH Chen et al.
GENES & DEVELOPMENT (2004)
Activity-dependent internalization of smoothened mediated by β-arrestin 2 and GRK2
W Chen et al.
SCIENCE (2004)
Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I
JH Jia et al.
NATURE (2004)
Functional characterization of sonic hedgehog mutations associated with holoprosencephaly
E Traiffort et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells
L Lum et al.
SCIENCE (2003)
Cholesterol modification of hedgehog is required for trafficking and movement, revealing an asymmetric cellular response to hedgehog
A Gallet et al.
DEVELOPMENTAL CELL (2003)
Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
JH Jia et al.
GENES & DEVELOPMENT (2003)
Mouse dispatched mutants fall to distribute hedgehog proteins and are defective in hedgehog signaling
T Kawakami et al.
DEVELOPMENT (2002)
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
JK Chen et al.
GENES & DEVELOPMENT (2002)
Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched
Y Ma et al.
CELL (2002)
Mouse dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling
T Caspary et al.
CURRENT BIOLOGY (2002)
Patched acts catalytically to suppress the activity of Smoothened
J Taipale et al.
NATURE (2002)
Protein kinase A deficiency causes axially localized neural tube defects in mice
YZ Huang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex
SY Cheng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Hedgehog signaling in animal development: paradigms and principles
PW Ingham et al.
GENES & DEVELOPMENT (2001)
Skinny Hedgehog, an acyltransferase required for palmitoylation and activity of the Hedgehog signal
Z Chamoun et al.
SCIENCE (2001)
A freely diffusible form of Sonic hedgehog mediates long-range signalling
X Zeng et al.
NATURE (2001)
Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1
PM Lewis et al.
CELL (2001)
An acylatable residue of hedgehog is differentially required in Drosophila and mouse limb development
JD Lee et al.
DEVELOPMENTAL BIOLOGY (2001)
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
J Taipale et al.
NATURE (2000)
Mapping Sonic hedgehog-receptor interactions by steric interference
RB Pepinsky et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
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