期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 286, 期 43, 页码 37778-37792出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M111.255455
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资金
- National Institutes of Health [R01 NS050131]
- Alberta Heritage Foundation for Medical Research (AHFMR)
- American Heart Association [SDG5280023]
- Indiana Clinical and Translational Sciences Institute
- National Institutes of Health, National Center for Research Resources [RR025761]
- Ralph W. and Grace M. Showalter foundation [A70-0-079212, A70-9-079138]
- Elwert Award in Medicine
- Larry Kays Medical Neuroscience Fellowship
- Canadian Institutes of Health Research
Background: CRMP2 is an axonal guidance protein that has been linked to NMDA receptor-mediated excitotoxicity. Results: A CRMP2 peptide protects against NMDA receptor-mediated excitotoxicity in vitro and in vivo following a traumatic brain injury. Conclusion: CRMP2 is a novel target for neuroprotection. Significance: Targeting CRMP2 could lead to development of neurotherapeutics against traumatic brain injury as well as other neuronal insults.
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