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Sathish Kumar et al.
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Oliver Wirths et al.
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Takami Tomiyama et al.
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Alzheimer's Aβ Peptides with Disease-Associated N-Terminal Modifications: Influence of Isomerisation, Truncation and Mutation on Cu2+ Coordination
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Henning Breyhan et al.
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Maike Hartlage-Ruebsamen et al.
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Jean Sevalle et al.
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M. Britschgi et al.
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Holger Cynis et al.
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Holger Cynis et al.
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Stephen Schilling et al.
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N-truncated amyloid-beta oligomers induce learning impairment and neuronal apoptosis
Ihsen Youssef et al.
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Oliver Wirths et al.
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Oliver Wirths et al.
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Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography
Jun Maeda et al.
JOURNAL OF NEUROSCIENCE (2007)
Monoclonal antibodies that target pathological assemblies of A beta
Mary P. Lambert et al.
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A beta Oligomers - a decade of discovery
Dominic M. Walsh et al.
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Stephan Schilling et al.
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Holger Cynis et al.
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H Lewis et al.
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A specific amyloid-β protein assembly in the brain impairs memory
S Lesné et al.
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β-amyloid is different in normal aging and in Alzheimer disease
A Piccini et al.
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Biological significance of isoaspartate and its repair system
T Shimizu et al.
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Role of water-soluble amyloid-β in the pathogenesis of Alzheimer's disease
M Tabaton et al.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (2005)
Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo
I Klyubin et al.
NATURE MEDICINE (2005)
Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor proteintransgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid β
MM Racke et al.
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Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions
S Schilling et al.
FEBS LETTERS (2004)
Oligomerization of Alzheimer's β-amyloid within processes and synapses of cultured neurons and brain
RH Takahashi et al.
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Massive CA1/2 neuronal loss with intraneuronal and N-interminal truncated Aβ42 accumulation in a novel Alzheimer transgenic model
C Casas et al.
AMERICAN JOURNAL OF PATHOLOGY (2004)
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O Wirths et al.
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Identification of human glutaminyl cyclase as a metalloenzyme - Potent inhibition by imidazole derivatives and heterocyclic chelators
S Schilling et al.
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Metal binding and oxidation of amyloid-β within isolated senile plaque cores:: Raman microscopic evidence
J Dong et al.
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β-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain
JT Huse et al.
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Soluble oligomers of β amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus
HW Wang et al.
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Phosphorylation of amyloid-β at the serine 26 residue by human cdc2 kinase
NGN Milton
NEUROREPORT (2001)
Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease
RB DeMattos et al.
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YM Kuo et al.
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Identification of amino-terminally and phosphotyrosine-modified carboxy-terminal fragments of the amyloid precursor protein in Alzheimer's disease and Down's syndrome brain
C Russo et al.
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SDS-stable complex formation between native apolipoprotein E3 and β-amyloid peptides
GW Munson et al.
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Y Harigaya et al.
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The oligomerization of amyloid β-protein begins intracellularly in cells derived from human brain
DM Walsh et al.
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Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
F Bard et al.
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C Russo et al.
NATURE (2000)
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