期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 286, 期 41, 页码 35989-35997出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M111.254201
关键词
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资金
- National Institutes of Health [P20 AA017837, 5R01 AA016399, R37 AA011876, P20 AA17069 (6017), R01 DK076852, R56AI089781, RC1HL099130, R01HL056086, T32DK007319, U01 AI074503]
- Case Western Reserve University [CTSA UL1RR024989]
Background: Chronic alcohol consumption leads to inflammation in adipose tissue, disrupting normal metabolic activity of adipocytes. Results: Expression of an alcohol metabolizing enzyme, cytochrome P4502E1, initiates inflammation in adipose. Bid-dependent apoptosis and activation of complement then exacerbate this initial response. Conclusion: Adipose inflammation during alcohol feeding develops in response to cytochrome P450 expression. Significance: Preventing adipose inflammation may prevent the pathphysiological effects of ethanol.
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