期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 286, 期 40, 页码 34497-34503出版社
ELSEVIER
DOI: 10.1074/jbc.M111.266312
关键词
-
资金
- Centro Grandi Attrezzature per la Ricerca Biomedica Universita degli Studi dell'Insubria
- PhD School in Biological and Medical Sciences
- University of Insubria (FAR)
- Centro Interuniversitario di Biotecnologie
- Fondazione Comunitaria del Varesotto-ONLUS
- Centro Insubre di Biotecnologie per la Salute Umana
Smooth muscle cells (SMCs) have a pivotal role in cardiovascular diseases and are responsible for hyaluronan (HA) deposition in thickening vessel walls. HA regulates SMC proliferation, migration, and inflammation, which accelerates neointima formation. We used the HA synthesis inhibitor 4-methylumbelliferone (4-MU) to reduce HA production in human aortic SMCs and found a significant increase of apoptotic cells. Interestingly, the exogenous addition of HA together with 4-MU reduced apoptosis. A similar anti-apoptotic effect was observed also by adding other glycosaminoglycans and glucose to 4-MU-treated cells. Furthermore, the anti-apoptotic effect of HA was mediated by Toll-like receptor 4, CD44, and PI3K but not by ERK1/2.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据