期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 286, 期 41, 页码 36020-36031出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M111.282145
关键词
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资金
- British Heart Foundation [RG/07/001]
- Medical Research Council [G0700903]
- Tenovus Scotland [T07/26]
- MRC [G0700903] Funding Source: UKRI
- British Heart Foundation [RG/07/001/22628, PG/10/93/28650] Funding Source: researchfish
- Medical Research Council [G0700903] Funding Source: researchfish
Background: Phospholemman regulates the plasmalemmal sodium pump in excitable tissues such as the heart. Results: Phospholemman is palmitoylated at two intracellular cysteines, and this reduces ion transport by the sodium pump. Conclusion: Phospholemman must be palmitoylated to inhibit the sodium pump. Significance: This is a potentially new way to regulate the sodium pump, an enzyme expressed in most eukaryotic cells.
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