期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 286, 期 25, 页码 22122-22130出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M111.236257
关键词
-
资金
- Alzheimer's Association
- Mitchell Center for Neurodegenerative Diseases
- Cullen Trust
Annular protofibrils (APFs) represent a new and distinct class of amyloid structures formed by disease-associated proteins. In vitro, these pore-like structures have been implicated in membrane permeabilization and ion homeostasis via pore formation. Still, evidence for their formation and relevance in vivo is lacking. Herein, we report that APFs are in a distinct pathway from fibril formation in vitro and in vivo. In human Alzheimer disease brain samples, amyloid-beta APFs were associated with diffuse plaques, but not compact plaques; moreover, we show the formation of intracellular APFs. Our results together with previous studies suggest that the prevention of amyloid-beta annular protofibril formation could be a relevant target for the prevention of amyloid-beta toxicity in Alzheimer disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据