期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 287, 期 6, 页码 4014-4022出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M111.312264
关键词
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资金
- Baylor College of Medicine
- Feinstein Institute North Shore-Long Island Jewish Health System General Clinical Research National Institutes of Health [M01RR018535]
- National Institutes of Health, NIAID [AI084981, AI54348]
- NINDS [NS042901]
- NIAMS [AR059838, AR0426213]
- National Institutes of Health [NCRR S10RR024574, NIAID AI036211, NCI P30CA125123]
Fibroblast-like synoviocytes (FLS) play important roles in the pathogenesis of rheumatoid arthritis (RA). Potassium channels have regulatory roles in many cell functions. We have identified the calcium-and voltage-gated KCa1.1 channel (BK, Maxi-K, Slo1, KCNMA1) as the major potassium channel expressed at the plasma membrane of FLS isolated from patients with RA (RA-FLS). We further show that blocking this channel perturbs the calcium homeostasis of the cells and inhibits the proliferation, production of VEGF, IL-8, and pro-MMP-2, and migration and invasion of RA-FLS. Our findings indicate a regulatory role of KCa1.1 channels in RA-FLS function and suggest this channel as a potential target for the treatment of RA.
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