期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 286, 期 40, 页码 34479-34485出版社
ELSEVIER
DOI: 10.1074/jbc.R111.290585
关键词
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资金
- Biotechnology and Biological Sciences Research Council [BB/F011520/1] Funding Source: Medline
- BBSRC [BB/F011520/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F011520/1] Funding Source: researchfish
All mechanisms of protein synthesis can be considered in four stages: initiation, elongation, termination, and ribosome recycling. Remarkable progress has been made in understanding how these processes are mediated in the cytosol of many species; however, details of organellar protein synthesis remain sketchy. This is an important omission, as defects in human mitochondrial translation are known to cause disease and may contribute to the aging process itself. In this minireview, we focus on the recent advances that have been made in understanding how one of these processes, translation termination, occurs in the human mitochondrion.
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