期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 286, 期 17, 页码 15268-15277出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M110.211813
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资金
- Deutsches Krebsforschungszentrum
- Israel Ministry of Science and Technology
We report that the activation level of AMP-dependent protein kinase AMPK is elevated in cancer cell lines as a hallmark of their transformed state. In OVCAR3 and A431 cells, c-Src signals through protein kinase C alpha, phospholipase C gamma, and LKB1 to AMPK. AMPK controls internal ribosome entry site (IRES) dependent translation in these cells. We suggest that AMPK activation via PKC might be a general mechanism to regulate IRES-dependent translation in cancer cells.
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