期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 286, 期 50, 页码 42981-42991出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M111.310599
关键词
-
资金
- National Institute of Health [AR056296, AI088177]
Background: Listeria monocytogenes is an intracellular pathogen that invades the host cytoplasm. Results: Cells deficient in TLR2 and NOD2 show defective autophagy of Listeria monocytogenes. Conclusion: Autophagy of Listeria is dependent on ERK pathway that is perturbed in TLR2- and NOD2-deficient cells. Significance: Our study establishes the role of innate immune receptors in autophagy of intracellular pathogens.
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