期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 286, 期 35, 页码 30245-30252出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R111.272690
关键词
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资金
- National Natural Science Foundation [20832009, 30525001, 20921091]
- Ministry of Science and Technology [2009ZX09501-008]
- National Basic Research Program (973 Program) [2010CB833200]
- Chinese Academy of Sciences [KJCX2-YW-H08]
- Science and Technology Commission of Shanghai Municipality [09QH1402700]
The radical S-adenosylmethionine (AdoMet) superfamily currently comprises thousands of proteins that participate in numerous biochemical processes across all kingdoms of life. These proteins share a common mechanism to generate a powerful 5'-deoxyadenosyl radical, which initiates a highly diverse array of biotransformations. Recent studies are beginning to reveal the role of radical AdoMet proteins in the catalysis of highly complex and chemically unusual transformations, e. g. the ThiC-catalyzed complex rearrangement reaction. The unique features and intriguing chemistries of these proteins thus demonstrate the remarkable versatility and sophistication of radical enzymology.
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