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Thomas Kindler et al.
BLOOD (2010)
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ANNUAL REVIEW OF BIOCHEMISTRY (2009)
Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality
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BLOOD (2009)
Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3
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CELLULAR SIGNALLING (2009)
Structural and Functional Alterations of FLT3 in Acute Myeloid Leukemia
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CLINICAL CANCER RESEARCH (2009)
Heat Shock Protein 90 as a Drug Target: Some Like It Hot
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CLINICAL CANCER RESEARCH (2009)
CBL Exon 8/9 Mutants Activate the FLT3 Pathway and Cluster in Core Binding Factor/11q Deletion Acute Myeloid Leukemia/Myelodysplastic Syndrome Subtypes
Carola Reindl et al.
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The fusion proteins TEL-PDGFRβ and FIP1L1-PDGFRα escape ubiquitination and degradation
Federica Toffalini et al.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2009)
The proteasomal system
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MOLECULAR ASPECTS OF MEDICINE (2009)
Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes
Chunaram Choudhary et al.
MOLECULAR CELL (2009)
Physiological functions of the HECT family of ubiquitin ligases
Daniela Rotin et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
The Hsp90 molecular chaperone: an open and shut case for treatment
Laurence H. Pearl et al.
BIOCHEMICAL JOURNAL (2008)
Heat shock protein 90 inhibition is cytotoxic to primary AML cells expressing mutant FLT3 and results in altered downstream signalling
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BRITISH JOURNAL OF HAEMATOLOGY (2008)
Transformation by oncogenic mutants and ligand-dependent activation of FLT3 wild-type requires the tyrosine residues 589 and 591
Sridhar Vempati et al.
CLINICAL CANCER RESEARCH (2008)
Mutant FLT3:: A direct target of sorafenib in acute myelogenous leukemia
Weiguo Zhang et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2008)
Sensitivity toward sorafenib and sunitinib varies between different activating and drug-resistant FLT3-ITD mutations
Rama Krishna Kancha et al.
EXPERIMENTAL HEMATOLOGY (2007)
Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized
David Padron et al.
CANCER RESEARCH (2007)
Flt3-dependent transformation by inactivating c-Cbl mutations in AML
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BLOOD (2007)
Synergism between etoposide and 17-AAG in leukemia cells: Critical roles for Hsp90, FLT3, topoisomerase II, Chk1, and Rad51
Qing Yao et al.
CLINICAL CANCER RESEARCH (2007)
The Cbl family proteins: Ring leaders in regulation of cell signaling
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JOURNAL OF CELLULAR PHYSIOLOGY (2006)
Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD
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BLOOD (2006)
Human leukemias with mutated FLT3 kinase are synergistically sensitive to FLT3 and Hsp90 inhibitors: the key role of the STAT5 signal transduction pathway
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LEUKEMIA (2005)
AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations
C Choudhary et al.
BLOOD (2005)
Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases
DE Schmidt-Arras et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Src family tyrosine kinases are activated by Flt3 and are involved in the proliferative effects of leukemia-associated Flt3 mutations
LJ Robinson et al.
EXPERIMENTAL HEMATOLOGY (2005)
Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: Implications for Lewy body formation
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JOURNAL OF NEUROSCIENCE (2005)
Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3
P George et al.
BLOOD (2005)
Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b
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ONCOGENE (2004)
Superior activity of the combination of histone deacetylase inhibitor LAQ824 and the FLT-3 kinase inhibitor PKC412 against human acute myelogenous leukemia cells with mutant FLT-3
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CLINICAL CANCER RESEARCH (2004)
Cotreatment with 17-allylamino-demethoxygeldanamycin and FLT-3 kinase inhibitor PKC412 is highly effective against human acute myelogenous leukemia cells with mutant FLT-3
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CANCER RESEARCH (2004)
WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
FLT3 mutations in acute myeloid leukemia cell lines
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LEUKEMIA (2003)
Selective apoptosis of tandemly duplicated FLT3-transformed leukemia cells by Hsp90 inhibitors
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LEUKEMIA (2002)
Sensitivity of mammalian cells expressing mutant ubiquitin to protein-damaging agents
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JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Plat-E: an efficient and stable system for transient packaging of retroviruses
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GENE THERAPY (2000)
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