期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 285, 期 50, 页码 39401-39408出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M110.103705
关键词
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资金
- Ruth Estrin Goldberg Memorial Foundation
- Tanzman Foundation
- Jon Runyan Score for the Cure
- Korean government Ministry of Education, Science, and Technology [09-1975-CCR-EO, PC 080209, R11-2008-014-00001-0]
Unlike the prototype transforming growth factor-beta (TGF-beta), bone morphogenetic protein-6 (BMP-6) activates macrophages. Here, we report that BMP-6 induces the expression of IL-6 in macrophages. Using overexpression and knockdown experiments, we demonstrate that BMP receptor type II and activin-like kinase-2 are necessary for IL-6 induction by BMP-6. At the intracellular level, both Smad and p38 signaling pathways are required for the induction of IL-6. The cross-talk between the two pathways occurs at the level of transcription factor GATA4 and Smad 1/4. These results, taken together, demonstrate a novel BMP-6 signaling mechanism in which both the Smad and non-Smad pathways directly interact to activate the transcription of a target gene.
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