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Nicolas Dumaz et al.
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C Rosse et al.
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NS Bryce et al.
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KH Lim et al.
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K Wennerberg et al.
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A González-García et al.
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High frequency of mutations of the PIK3CA gene in human cancers
Y Samuels et al.
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M Shipitsin et al.
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RalA activation at nascent lamellipodia of epidermal growth factor-stimulated Cos7 cells and migrating Madin-Darby canine kidney Cells
A Takaya et al.
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P Rodriguez-Viciana et al.
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DR Rhodes et al.
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Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf
TM Lanigan et al.
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Distinct requirements for Ras oncogenesis in human versus mouse cells
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GRA Ehrhardt et al.
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The human RGL (RalGDS-like) gene:: cloning, expression analysis and genomic organization
R Sood et al.
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