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Michelle L. Stewart et al.
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The BCL-2 protein family: opposing activities that mediate cell death
Richard J. Youle et al.
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In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas
Kylie D. Mason et al.
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Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins
Jerry E. Chipuk et al.
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Rachel T. Uren et al.
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Simon N. Willis et al.
SCIENCE (2007)
Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737
Victoria Del Gaizo Moore et al.
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The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site
Tudor Moldoveanu et al.
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Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies
Hyungjin Kim et al.
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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
Mark F. van Delft et al.
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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
Marina Konopleva et al.
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A stapled BID BH3 helix directly binds and activates BAX
Loren D. Walensky et al.
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Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario
J. E. Chipuk et al.
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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
Michael Certo et al.
CANCER CELL (2006)
The multidomain proapoptotic molecules Bax and Bak are directly activated by heat
LJ Pagliari et al.
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An inhibitor of Bcl-2 family proteins induces regression of solid tumours
T Oltersdorf et al.
NATURE (2005)
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
SN Willis et al.
GENES & DEVELOPMENT (2005)
Do inducers of apoptosis trigger caspase-independent cell death?
JE Chipuk et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
BH3 domains of BH3-only proteins differentially regulate bax-mediated mitochondrial membrane permeabilization both directly and indirectly
T Kuwana et al.
MOLECULAR CELL (2005)
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
JE Chipuk et al.
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Cell death: Critical control points
NN Danial et al.
CELL (2004)
BCL-2 selectively interacts with the BID-induced open conformer of BAK, inhibiting BAK auto-oligomerization
SC Ruffolo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Bcl-2-family proteins and the role of mitochondria in apoptosis
T Kuwana et al.
CURRENT OPINION IN CELL BIOLOGY (2003)
Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane
T Kuwana et al.
CELL (2002)
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
A Letai et al.
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Cellular damage signals promote sequential changes at the N-terminus and BH-1 domain of the pro-apoptotic protein Bak
GJ Griffiths et al.
ONCOGENE (2001)
Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis
A Nechushtan et al.
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Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
MC Wei et al.
SCIENCE (2001)
Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells
B Antonsson et al.
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The combined functions of proapoptotic Bcl-2 family members Bak and Bax are essential for normal development of multiple tissues
T Lindsten et al.
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