期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 285, 期 35, 页码 26753-26759出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R110.119503
关键词
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资金
- National Institutes of Health [R01 DK74797, R01 DK85035, R01 DK70838, P01 HL032262, P30 DK072437]
- Netherlands Organization for Scientific Research (NWO)
- March of Dimes Foundation
- Roche Foundation for Anemia Research
Iron is an essential element for diverse biological functions. In mammals, the majority of iron is enclosed within a single prosthetic group: heme. In metazoans, heme is synthesized via a highly conserved and coordinated pathway within the mitochondria. However, iron is acquired from the environment and subsequently assimilated into various cellular pathways, including heme synthesis. Both iron and heme are toxic but essential cofactors. How is iron transported from the extracellular milieu to the mitochondria? How are heme and heme intermediates coordinated with iron transport? Although recent studies have answered some questions, several pieces of this intriguing puzzle remain unsolved.
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