期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 285, 期 32, 页码 24404-24411出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M110.112599
关键词
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资金
- Canada Foundation of Innovation
- Natural Sciences and Engineering Research Council of Canada
- Ontario HIV Treatment Network Studentship
- Canadian Institutes of Health Research Vanier Award
- Ministry of Higher Education, Malasia
- Universiti Sains Malaysia
IL-27 is a heterodimeric cytokine bridging innate and adaptive immunity by playing a role in the activation of naive T cells and in development of Th1 cells. Additionally, recent evidence supports a role for IL-27 in the activation of monocytic cells. Both pro-inflammatory and anti-inflammatory activities have been attributed to IL-27; however, the role played by IL-27 in the activation of human monocytic cells in terms of cytokine production has not been well described. Our results show that IL-27 is a strong inducer of proinflammatory cytokine and chemokine expression, including enhancement of IL-6, IP- 10, MIP-1 alpha, MIP-1 beta, and TNF-alpha expression in human primary monocytes. Furthermore, we observed that IL-27-induced cytokine and chemokine production was mediated by STAT1, STAT3, and NF-kappa B activation. Understanding how IL-27 exerts its effects on monocytic cells will identify important molecular mechanisms in the regulation of immune responses, particularly in the modulation of monocyte activation.
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