期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 284, 期 31, 页码 20869-20875出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M109.002923
关键词
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资金
- Danscatt consortium
- Novo Nordisk Foundation
- Danish Medical Research Council [22-04-0704]
- Carlsberg Foundation
- Arne Hansen stipend
Interferon-lambda (IFN-lambda) is an antiviral cytokine that signals through a distinct receptor complex, composed of the IFN-lambda R1 and interleukin-10R2 (IL-10R2) receptor chains. We have determined the crystal structure of human IFN-lambda 3 and characterized the interaction with its receptor complex through structure-based site-directed mutagenesis. The ability of IFN-lambda 3 mutants to signal was determined by measuring the antiviral activity and induced STAT2 phosphorylation. In conclusion, our data show that, although IFN-lambda is functionally an interferon, it is clearly structurally related to members of the IL-10 family. In particular, we found an interesting similarity between IFN-lambda and IL-22, and we suggest that IFN-lambda and IL-22 possess parallel functions, protecting epithelial tissue against viral and bacterial infections, respectively.
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