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Andrea B. Eberle et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay
Olaf Isken et al.
CELL (2008)
Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways
Pavel V. Ivanov et al.
EMBO JOURNAL (2008)
NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity
Hala Chamieh et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)
Communication with the Exon-Junction complex and activation of nonsense-mediated decay by human Upf proteins occur in the cytoplasm
Guramrit Singh et al.
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Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function
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GENES & DEVELOPMENT (2007)
Human INT6/eIF3e is required for nonsense-mediated mRNA decay
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Substrate-dependent targeting of eukaryotic translation initiation factor 4A by pateamine A: Negation of domain-linker regulation of activity
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CHEMISTRY & BIOLOGY (2007)
Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Eukaryotic initiation factor 2α-independent pathway of stress granule induction by the natural product pateamine A
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA
Christian B. F. Andersen et al.
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Dead-box proteins: a family affair - active and passive players in RNP-remodeling
Patrick Linder
NUCLEIC ACIDS RESEARCH (2006)
Specific inhibition of nonsense-mediated mRNA decay components, SMG-1 or Upf1, rescues the phenotype of Ullrich disease fibroblasts
Fusako Usuki et al.
MOLECULAR THERAPY (2006)
The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA
Fulvia Bono et al.
CELL (2006)
The three-dimensional architecture of the EJC core
M. Elizabeth Stroupe et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
Internal ribosome entry sequence-mediated translation initiation triggers nonsense-mediated decay
Jill A. Holbrook et al.
EMBO REPORTS (2006)
Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay
T Shibuya et al.
RNA (2006)
hUPF2 silencing identifies physiologic substrates of mammalian nonsense-mediated mRNA decay
J Wittmann et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay
I Kashima et al.
GENES & DEVELOPMENT (2006)
Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation
Joachim B. Kunz et al.
RNA (2006)
The role of SMG-1 in nonsense-mediated mRNA decay
A Yamashita et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2005)
Inhibition of eukaryotic translation initiation by the marine natural product pateamine A
WK Low et al.
MOLECULAR CELL (2005)
Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements
NH Gehring et al.
MOLECULAR CELL (2005)
The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity
L Ballut et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)
Smg1 nonsense mutations do not abolish nonsense-mediated mRNA decay in Drosophila melanogaster
ZZ Chen et al.
GENETICS (2005)
Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation
ME Bordeleau et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells
F Lejeune et al.
CURRENT OPINION IN CELL BIOLOGY (2005)
eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay
T Shibuya et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)
A nuclear translation-like factor elF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay
MA Ferraiuolo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay
IM Palacios et al.
NATURE (2004)
Evidence for separate binding and scaffolding domains in the immunosuppressive and antitumor marine natural product, pateamine A: Design, synthesis, and activity studies leading to a potent simplified derivative
D Romo et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA decay in Caenorhabditis elegans
A Grimson et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
New insights into the formation of active nonsensemediated decay complexes
G Singh et al.
TRENDS IN BIOCHEMICAL SCIENCES (2003)
Y14 and hUpf3b form an NMD-activating complex
NH Gehring et al.
MOLECULAR CELL (2003)
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7
T Ohnishi et al.
MOLECULAR CELL (2003)
Characterization of human Smg5/7a: A protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1
SY Chiu et al.
RNA (2003)
Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts
JT Mendell et al.
SCIENCE (2002)
A quality control pathway that down-regulates aberrant T-cell receptor (TCR) transcripts by a mechanism requiring UPF2 and translation
J Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20
Y Ishigaki et al.
CELL (2001)
The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay
H Le Hir et al.
EMBO JOURNAL (2001)
Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay
A Yamashita et al.
GENES & DEVELOPMENT (2001)
Cloning of a novel phosphatidylinositol kinase-related kinase - Characterization of the human SMG-1 RNA surveillance protein
G Denning et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Induction of apoptosis by the marine sponge (Mycale) metabolites, mycalamide A and pateamine
KA Hood et al.
APOPTOSIS (2001)
A strategy for disease gene identification through nonsense-mediated mRNA decay inhibition
EN Noensie et al.
NATURE BIOTECHNOLOGY (2001)
Evidence that phosphorylation of human Upf1 protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathway
M Pal et al.
RNA (2001)
The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions
H Le Hir et al.
EMBO JOURNAL (2000)
Peloruside A:: A potent cytotoxic macrolide isolated from the New Zealand marine sponge Mycale sp.
LM West et al.
JOURNAL OF ORGANIC CHEMISTRY (2000)
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