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Peter C. Harris et al.
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Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound
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Molecular determinants of sensitivity and conductivity of human TRPM7 to Mg2+ and Ca2+
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Off-response property of an acid-activated cation channel complex PKD1L3-PKD2L1
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Formation of a new receptor-operated channel by heteromeric assembly of TRPP2 and TRPC1 subunits
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TRPP2 and TRPV4 form a polymodal sensory channel complex
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TrpC3 Regulates Hypertrophy-Associated Gene Expression without Affecting Myocyte Beating or Cell Size
Jacob S. Brenner et al.
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TRPC channels promote cerebellar granule neuron survival
Yichang Jia et al.
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Dissecting ICRAC, a store-operated calcium current
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TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy
Naoya Onohara et al.
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Canonical transient receptor potential channels promote cardiomyocyte hypertrophy through activation of calcineurin signaling
Erik W. Bush et al.
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Calcineurin-dependent cardiomyopathy is activated by TRPC in the adult mouse heart
Hiroyuki Nakayama et al.
FASEB JOURNAL (2006)
Haploinsufficiency of Pkd2 is associated with increased tubular cell proliferation and interstitial fibrosis in two murine Pkd2 models
Ming Yang Chang et al.
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Identification and localization of TRPC channels in the rat kidney
M Goel et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2006)
Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif
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Polycystin-2 regulates proliferation and branching morphogenesis in kidney epithelial cells
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Ca2+ signaling microdomains: platforms for the assembly and regulation of TRPC channels
IS Ambudkar
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Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling
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JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor ld2
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NATURE CELL BIOLOGY (2005)
Autosomal-dominant polycystic kidney disease in infancy and childhood: Progression and outcome
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PKD2 functions as an epidermal growth factor-activated plasma membrane channel
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MOLECULAR AND CELLULAR BIOLOGY (2005)
The non-selective cation-permeable channel TRPC3 is a tetrahedron with a cap on the large cytoplasmic end
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Alpha-actinin associates with polycystin-2 and regulates its channel activity
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HUMAN MOLECULAR GENETICS (2005)
Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor
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NATURE (2005)
Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells -: Role in apical Ca2+ influx
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JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation
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EMBO JOURNAL (2005)
A polycystin-1 multiprotein complex is disrupted in polycystic kidney disease cells
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MOLECULAR BIOLOGY OF THE CELL (2004)
Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells - Role of mDia1 in PKD2 localization to mitotic spindles
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Amplification of receptor signalling by Ca2+ entry-mediated translocation and activation of PLCγ2 in B lymphocytes
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EMBO JOURNAL (2003)
Pkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cells
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HUMAN MOLECULAR GENETICS (2003)
TRPC3 mediates T-cell receptor-dependent calcium entry in human T-lymphocytes
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Signaling mechanism for receptor-activated canonical transient receptor potential 3 (TRPC3) channels
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia
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MOLECULAR AND CELLULAR BIOLOGY (2003)
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
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NATURE GENETICS (2003)
The ion channel polycystin-2 is required for left-right axis determination in mice
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CURRENT BIOLOGY (2002)
Polycystin-2 is an intracellular calcium release channel
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NATURE CELL BIOLOGY (2002)
Transport function of the naturally occurring pathogenic polycystin-2 mutant, R742X
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
Polycystin-2 is a novel cation channel implicated in defective intracellular Ca2+ homeostasis in polycystic kidney disease
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
Effect of ACE gene polymorphism on age at renal death in polycystic kidney disease in Japan
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AMERICAN JOURNAL OF KIDNEY DISEASES (2001)
Co-assembly of polycystin-1 and-2 produces unique cation-permeable currents
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NATURE (2000)
In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2
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JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Characterization using FLIPR of rat vanilloid receptor (rVR1) pharmacology
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BRITISH JOURNAL OF PHARMACOLOGY (2000)
Location of mutations within the PKD2 gene influences clinical outcome
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KIDNEY INTERNATIONAL (2000)