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Zezhou Wang et al.
EMBO JOURNAL (2009)
Numb Regulates Post-endocytic Trafficking and Degradation of Notch1
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JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Diacylglycerol analogues activate second messenger-operated calcium channels exhibiting TRPC-like properties in cortical neurons
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Store-operated Ca2+ channels formed by TRPC1, TRPC6 and Orai1 and non-store-operated channels formed by TRPC3 are involved in the regulation of NADPH oxidase in HL-60 granulocytes
S. Brechard et al.
CELL CALCIUM (2008)
Numb Endocytic adapter proteins regulate the transport and processing of the amyloid precursor protein in an isoform-dependent manner - Implications for Alzheimer disease pathogenesis
George A. Kyriazis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Endosomal entry regulates Notch receptor activation in Drosophila melanogaster
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Calcineurin is involved in the early activation of NMDA-mediated cell death in mutant huntingtin knock-in striatal cells
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JOURNAL OF NEUROCHEMISTRY (2008)
The Notch pathway in podocytes plays a role in the development of glomerular disease
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NATURE MEDICINE (2008)
Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice
Kelly T. Dineley et al.
NEUROBIOLOGY OF LEARNING AND MEMORY (2007)
Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3
Takashi Nishimura et al.
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Orai proteins interact with TRPC channels and confer responsiveness to store depletion
Yanhong Liao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Induction of TRPC6 channel in acquired forms of proteinuric kidney disease
Clemens C. Moeller et al.
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Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neural cells
Sic. L. Chan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Notch signaling in cancer
Lucio Miele et al.
CURRENT MOLECULAR MEDICINE (2006)
TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling
Koichiro Kuwahara et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch- dependent ubiquitination
Lucia Di Marcotullio et al.
NATURE CELL BIOLOGY (2006)
Transient receptor potential channels in cardiovascular function and disease
Ryuji Inoue et al.
CIRCULATION RESEARCH (2006)
Gamma secretase-mediated notch signaling worsens brain damage and functional outcome in ischemic stroke
TV Arumugam et al.
NATURE MEDICINE (2006)
Aberrant activation of Notch signaling in human breast cancer
S Stylianou et al.
CANCER RESEARCH (2006)
The diacylgylcerol-sensitive TRPC3/6/7 subfamily of cation channels: functional characterization and physiological relevance
A Dietrich et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2005)
Activation of M1 muscarinic acetylcholine receptors stimulates the formation of a multiprotein complex centered on TRPC6 channels
JY Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
A store-operated Ca2+ influx activated in response to the depletion of thapsigargin-sensitive Ca2+ stores is developmentally regulated in embryonic cortical neurons from mice
A Bouron et al.
DEVELOPMENTAL BRAIN RESEARCH (2005)
Numb and α-adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs
A Hutterer et al.
EMBO REPORTS (2005)
Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells
TK Zagranichnaya et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Integration of Notch 1 and Calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control
C Mammucari et al.
DEVELOPMENTAL CELL (2005)
Notch-1 activation and dendritic atrophy in prion disease
N Ishikura et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Structural characterization, tissue distribution, and functional expression of murine aminoacylase III
A Pushkin et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2004)
Intracellular calcium signals and control of cell proliferation: how many mechanisms?
L Munaron et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2004)
Herp stabilizes neuronal Ca2+ homeostasis and mitochondrial function during endoplasmic reticulum stress
SL Chan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Involvement of Notch signaling in hippocampal synaptic plasticity
Y Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis
S Pece et al.
JOURNAL OF CELL BIOLOGY (2004)
Transcriptional regulation by calcium, calcineurin, and NFAT
PG Hogan et al.
GENES & DEVELOPMENT (2003)
Learning and memory deficits in Notch mutant mice
RM Costa et al.
CURRENT BIOLOGY (2003)
Calcium signalling: Dynamics, homeostasis and remodelling
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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)
Mammalian numb proteins promote notch1 receptor ubiquitination and degradation of the notch1 intracellular domain
MA McGill et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
HES and HERP families: Multiple effectors of the Notch signaling pathway
T Iso et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2003)
Keeping a good pathway down: transcriptional repression of Notch pathway target genes by CSL proteins
EC Lai
EMBO REPORTS (2002)
Numb isoforms containing a short PTB domain promote neurotrophic factor-induced differentiation and neurotrophic factor withdrawal-induced death of PC12 cells
WA Pedersen et al.
JOURNAL OF NEUROCHEMISTRY (2002)
The γ-secretase-generated intracellular domain of β-amyloid precursor protein binds Numb and inhibits Notch signaling
R Roncarati et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP
MA Leissring et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
c-Cbl binding and ubiquitin-dependent lysosomal degradation of membrane-associated Notch1
BM Jehn et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Store-operated Ca2+ entry uncoupled with ryanodine receptor and junctional membrane complex in heart muscle cells
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CELL CALCIUM (2002)
Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method
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METHODS (2001)
Dysregulation of cellular calcium homeostasis in Alzheimer's disease - Bad genes and bad habits
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JOURNAL OF MOLECULAR NEUROSCIENCE (2001)
A diacylglycerol-activated Ca2+ channel in PC12 cells (an adrenal chromaffin cell line) correlates with expression of the TRP-6 (transient receptor potential) protein
Y Tesfai et al.
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A transcriptively active complex of APP with Fe65 and histone acetyltransferase Tip60
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SCIENCE (2001)
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A common enzyme connects Notch signaling and Alzheimer's disease
R Kopan et al.
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Carboxyl-terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity
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FASEB JOURNAL (2000)
Multiple modes of peptide recognition by the PTB domain of the cell fate determinant Numb
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EMBO JOURNAL (2000)
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