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Kristina Hedbacker et al.
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Access denied: Snf1 activation loop phosphorylation is controlled by availability of the phosphorylated threonine 210 to the PP1 phosphatase
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Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1
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Structural basis for AMP binding to mammalian AMP-activated protein kinase
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Regulation of Snf1 protein kinase in response to environmental stress
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Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade
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Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the γ subunit
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Structure of the Bateman2 domain of yeast Snf4: Dimeric association and relevance of AMP binding
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The transcriptional response of the yeast Na+-ATPase ENA1 gene to alkaline stress involves three main signaling pathways
Maria Platara et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Regulation of the nucleocytoplasmic distribution of Snf1-Gal83 protein kinase
Kristina Hedbacker et al.
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Nitrogen availability and TOR regulate the Snf1 protein kinase in Saccharomyces cerevisiae
Marianna Orlova et al.
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Dissecting the role of 5′-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase
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Subunits of the Snf1 kinase heterotrimer show interdependence for association and activity
Karin Elbing et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro
Milica Momcilovic et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Requirement of ELC1 for RNA polymerase II polyubiquitylation and degradation in response to DNA damage in Saccharomyces cerevisiae
Balazs Ribar et al.
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Structural basis for glycogen recognition by AMP-activated protein kinase
G Polekhina et al.
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N488I mutation of the γ2-subunit results in bidirectional changes in AMP-activated protein kinase activity
LQ Zou et al.
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The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases
RL Hurley et al.
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Ca2+/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells
A Woods et al.
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Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase
SA Hawley et al.
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Function of mammalian LKB1 and Ca2+/calmodulin-dependent protein kinase kinase a as Snf1-activating kinases in yeast
SP Hong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Fatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the γ2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency
B Burwinkel et al.
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A role for the non-phosphorylated form of yeast Snf1: tolerance to toxic cations and activation of potassium transport
F Portillo et al.
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AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
BB Kahn et al.
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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
RJ Shaw et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The protein kinase snf1 is required for tolerance to the ribonucleotide reductase inhibitor hydroxyurea
C Dubacq et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Pak1 protein kinase regulates activation and nuclear localization of Snf1-Gal83 protein kinase
K Hedbacker et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
The NEF4 complex regulates Rad4 levels and utilizes Snf2/Swi2-related ATPase activity for nucleotide excision repair
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MOLECULAR AND CELLULAR BIOLOGY (2004)
CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations
JW Scott et al.
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Mutations in the Gal83 glycogen-binding domain activate the Snf1/Gal83 kinase pathway by a glycogen-independent mechanism
HA Wiatrowski et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Intrasteric control of AMPK via the gamma(1) subunit AMP allosteric regulatory site
J Adams et al.
PROTEIN SCIENCE (2004)
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
A Woods et al.
CURRENT BIOLOGY (2003)
Global analysis of protein expression in yeast
S Ghaemmaghami et al.
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Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex
CM Sutherland et al.
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Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases
SP Hong et al.
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Multiple pathways are co-regulated by the protein kinase Snf1 and the transcription factors Adr1 and Cat8
ET Young et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy
M Arad et al.
CIRCULATION (2003)
Yeast Pak1 kinase associates with and activates Snf1
N Nath et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
AMPK β subunit targets metabolic stress sensing to glycogen
G Polekhina et al.
CURRENT BIOLOGY (2003)
Isolation of mutations in the catalytic domain of the Snf1 kinase that render its activity independent of the Snf4 subunit
A Leech et al.
EUKARYOTIC CELL (2003)
Functional analysis of mutations in the γ2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndrome
T Daniel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Snf1 protein kinase and the repressors Nrg1 and Nrg2 regulate FLO11, haploid invasive growth, and diploid pseudohyphal differentiation
S Kuchin et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Binding to Elongin C inhibits degradation of interacting proteins in yeast
LE Hyman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy
M Arad et al.
JOURNAL OF CLINICAL INVESTIGATION (2002)
Novel PRKAG2 mutation responsible for the genetic syndrome of ventricular preexcitation and conduction system disease with childhood onset and absence of cardiac hypertrophy
MH Gollob et al.
CIRCULATION (2001)
Regulation of Snf1 kinase - Activation requires phosphorylation of threonine 210 by an upstream kinase as well as a distinct step mediated by the Snf4 subunit
RR McCartney et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
An activating mutation in the γ1 subunit of the AMP-activated protein kinase
SR Hamilton et al.
FEBS LETTERS (2001)
Identification of a gene responsible for familial Wolff-Parkinson-White syndrome
MH Gollob et al.
NEW ENGLAND JOURNAL OF MEDICINE (2001)
Mutations in the γ2 subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy:: evidence for the central role of energy compromise in disease pathogenesis
E Blair et al.
HUMAN MOLECULAR GENETICS (2001)
Subcellular localization of the Snf1 kinase is regulated by specific β subunits and a novel glucose signaling mechanism
O Vincent et al.
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A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle
D Milan et al.
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Novel roles for Elongin C in yeast
T Jackson et al.
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Regulatory interactions between the Reg1-Glc7 protein phosphatase and the Snf1 protein kinase
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