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W. P. Wilkins et al.
CURRENT DRUG TARGETS (2008)
The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral Sphingomyelinase
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BIOCHEMISTRY (2007)
Intersectin-1s regulates the mitochondrial apoptotic pathway in endothelial cells
Sanda A. Predescu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
4-HPR-mediated leukemia cell cytotoxicity is triggered by ceramide-induced mitochondrial oxidative stress and is regulated downstream by Bcl-2
Maria-Celia Morales et al.
FREE RADICAL RESEARCH (2007)
ER stress-induced apoptosis and caspase-12 activation occurs downstream of mitochondrial apoptosis involving Apaf-1
Hiroshi Shiraishi et al.
JOURNAL OF CELL SCIENCE (2006)
Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario
J. E. Chipuk et al.
CELL DEATH AND DIFFERENTIATION (2006)
WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic β-cells
T Yamada et al.
HUMAN MOLECULAR GENETICS (2006)
The apoptosome: Physiological, developmental, and pathological modes of regulation
Zachary T. Schafer et al.
DEVELOPMENTAL CELL (2006)
Endoplasmic reticulum stress-induced apoptosis - Multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53
JZ Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Endoplasmic reticulum stress induces apoptosis by an apoptosome-dependent but caspase 12-independent mechanism
F Di Sano et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Ceramide forms channels in mitochondrial outer membranes at physiologically relevant concentrations
Leah J. Siskind et al.
MITOCHONDRION (2006)
Thrombospondin-1 C-terminal-derived peptide protects thyroid cells from ceramide-induced apoptosis through the adenylyl cyclase pathway
G. M. Rath et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2006)
Mechanisms of cytochrome c release from mitochondria
C. Garrido et al.
CELL DEATH AND DIFFERENTIATION (2006)
WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic β-cells
SG Fonseca et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Ceramide activates a mitochondrial p38 mitogen-activated protein kinase: A potential mechanism for loss of mitochondrial transmembrane potential and apoptosis
JY Kong et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2005)
Mitochondrial ceramide and the induction of apoptosis
LJ Siskind
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2005)
A mitochondrial pool of sphingomyelin is involved in TNFα-induced Bax translocation to mitochondria
H Birbes et al.
BIOCHEMICAL JOURNAL (2005)
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic β-cells
AK Cardozo et al.
DIABETES (2005)
Mitochondrial ceramide increases in UV-irradiated HeLa cells and is mainly derived from hydrolysis of sphingomyelin
Q Dai et al.
ONCOGENE (2004)
Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2β) and suppressed by inhibition of iPLA2β
S Ramanadham et al.
BIOCHEMISTRY (2004)
Biologically active sphingolipids in cancer pathogenesis and treatment
B Ogretmen et al.
NATURE REVIEWS CANCER (2004)
The pathophysiology of mitochondrial cell death
DR Green et al.
SCIENCE (2004)
Herp stabilizes neuronal Ca2+ homeostasis and mitochondrial function during endoplasmic reticulum stress
SL Chan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Opposite regulation of the mitochondrial apoptotic pathway by C2-ceramide and PACAP through a MAP-kinase-dependent mechanism in cerebellar granule cells
A Falluel-Morel et al.
JOURNAL OF NEUROCHEMISTRY (2004)
Smac induces cytochrome c release and apoptosis independently from Bax/Bcl-xL in a strictly caspase-3-dependent manner in human carcinoma cells
A Hasenjäger et al.
ONCOGENE (2004)
Involvement of ceramide in the mechanism of Cr(VI)-induced apoptosis of CHO cells
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FREE RADICAL RESEARCH (2004)
The expression and function of a group VIA calcium-independent phospholipase A2 (iPLA2β) in β-cells
J Turk et al.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2004)
Increased β-cell apoptosis prevents adaptive increase in β-cell mass in mouse model of type 2 diabetes -: Evidence for role of islet amyloid formation rather than direct action of amyloid
AE Butler et al.
DIABETES (2003)
Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis
CL Kelpe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Selective β-cell loss and β-cell expansion in patients with type 2 diabetes mellitus in Korea
KH Yoon et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)
Ceramide increases mitochondrial free calcium levels via caspase 8 and Bid: role in initiation of cell death
F Darios et al.
JOURNAL OF NEUROCHEMISTRY (2003)
Ceramide: second messenger or modulator of membrane structure and dynamics?
WJ van Blitterswijk et al.
BIOCHEMICAL JOURNAL (2003)
beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
AE Butler et al.
DIABETES (2003)
Translational control in the endoplasmic reticulum stress response
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JOURNAL OF CLINICAL INVESTIGATION (2002)
The endoplasmic reticulum: a multifunctional signaling organelle
MJ Berridge
CELL CALCIUM (2002)
Endoplasmic reticulum stress-mediated apoptosis in pancreatic β-cells
S Oyadomari et al.
APOPTOSIS (2002)
Biochemical identification of a neutral sphingomyelinase 1 (NSM1)-like enzyme as the major NSM activity in the DT40 B-cell line: absence of a role in the apoptotic response to endoplasmic reticulum stress
AC Fensome et al.
BIOCHEMICAL JOURNAL (2002)
Coupling endoplasmic reticulum stress to the cell death program - An Apaf-1-independent intrinsic pathway
RV Rao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Na/Ca exchanger overexpression induces endoplasmic reticulum-related apoptosis and caspase-12 activation in insulin-releasing BRIN-BD11 cells
O Diaz-Horta et al.
DIABETES (2002)
Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets -: Evidence that β-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
R Lupi et al.
DIABETES (2002)
Characterization of ceramides by low energy collisional-activated dissociation tandem mass spectrometry with negative-ion electrospray ionization
FF Hsu et al.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2002)
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes
S Oyadomari et al.
JOURNAL OF CLINICAL INVESTIGATION (2002)
Calcium and oxidative stress: from cell signaling to cell death
G Ermak et al.
MOLECULAR IMMUNOLOGY (2002)
β-cell death during progression to diabetes
D Mathis et al.
NATURE (2001)
Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway
S Oyadomari et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain
K Takeda et al.
HUMAN MOLECULAR GENETICS (2001)
Structural basis of IAP recognition by Smac/DIABLO
G Wu et al.
NATURE (2000)
Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c
SJ Korsmeyer et al.
CELL DEATH AND DIFFERENTIATION (2000)
Mitochondria and calcium: from cell signalling to cell death
MR Duchen
JOURNAL OF PHYSIOLOGY-LONDON (2000)
The machinery of local Ca2+ signalling between sarcoendoplasmic reticulum and mitochondria
G Hajnóczky et al.
JOURNAL OF PHYSIOLOGY-LONDON (2000)
EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome
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NATURE GENETICS (2000)
Structural determination of sphingomyelin by tandem mass spectrometry with electrospray ionization
FF Hsu et al.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2000)
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