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Jon C. Aster et al.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2008)
Regulation of apoptosis-inducing factor-mediated, cisplatin-induced apoptosis by Akt
X. Yang et al.
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The forkhead transcription factor FOXO4 sensitizes cancer cells to doxorubicin-mediated cytotoxicity
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Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break
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Critical roles of the PI3K/Akt signaling pathway in T cell development
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The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
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PKBα/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival
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P53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK
Karen A. Boehme et al.
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Cell signaling - Tel2 finally tells one story
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Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death
Hong-Gang Yu et al.
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Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways
Jerome Tamburini et al.
BLOOD (2008)
TeI2 regulates the stability of PI3K-related protein kinases
Hiroyuki Takai et al.
CELL (2007)
mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor
Janine Masri et al.
CANCER RESEARCH (2007)
Tel2: a common partner of PIK-related kinases and a link between DNA checkpoint and nutritional response?
Junko Kanoh et al.
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FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf
Caroline Bouchard et al.
GENES & DEVELOPMENT (2007)
Deletion of PKBα/Akt1 Affects Thymic Development
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Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia
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Akt1 and Akt2 are required for αβ thyrnocyte survival and differentiation
Marisa M. Juntilla et al.
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Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia
Steven M. Chan et al.
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AKT/PKB signaling: Navigating downstream
Brendan D. Manning et al.
CELL (2007)
Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition
Changchuin Mao et al.
JOURNAL OF IMMUNOLOGY (2007)
Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
Zhihong Zeng et al.
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FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
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CELL (2007)
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
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CELL (2007)
Stressing the role of FoxO proteins in lifespan and disease
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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCα but not S6K1
David A. Guertin et al.
DEVELOPMENTAL CELL (2006)
Cisplatin induces PKB/Akt activation and p38MAPK phosphorylation of the EGF receptor
S. E. Winograd-Katz et al.
ONCOGENE (2006)
Life with a single isoform of Akt: Mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies
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Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
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GENES & DEVELOPMENT (2006)
Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability
Chiyo Shiota et al.
DEVELOPMENTAL CELL (2006)
Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441
Yan Zhao et al.
CANCER RESEARCH (2006)
Ultraviolet radiation attenuates thrombospondin 1 expression via PI3K-Akt activation in human keratinocytes
Mi-Sun Kim et al.
PHOTOCHEMISTRY AND PHOTOBIOLOGY (2006)
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
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MOLECULAR CELL (2006)
Cisplatin activates Akt in small cell lung cancer cells and attenuates apoptosis by survivin upregulation
LL Belyanskaya et al.
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FOXO transcription factors at the interface between longevity and tumor suppression
EL Greer et al.
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Essential role of protein kinase Bγ (PKBγ/Akt3) in postnatal brain development but not in glucose homeostasis
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Role for Akt3/Protein kinase Bγ in attainment of normal brain size
RM Easton et al.
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DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA
AM Dragoi et al.
EMBO JOURNAL (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
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SCIENCE (2005)
Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM
JG Viniegra et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Differential responses to doxorubicin-induced phosphorylation and activation of Akt in human breast cancer cells
XQ Li et al.
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Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice
S Espejel et al.
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Physiological functions of protein kinase B/Akt
ZZ Yang et al.
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Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase
JH Feng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
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Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation
JH Feng et al.
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Role of DNA-PK in the cellular response to DNA double-strand breaks
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DNA REPAIR (2004)
Involvement of illegitimate V(D)J recombination or microhomology-mediated nonhomologous end-joining in the formation of intragenic deletions of the Notch1 gene in mouse thymic lymphomas
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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
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Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma
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Radiation-induced deletions in the 5′ end region of Notch1 lead to the formation of truncated proteins and are involved in the development of mouse thymic lymphomas
H Tsuji et al.
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Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBβ
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EL Whiteman et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2002)
Elevated myocardial Akt signaling ameliorates doxorubicin-induced congestive heart failure and promotes heart growth
Y Taniyama et al.
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Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B
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Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus
S Malstrom et al.
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DP Brazil et al.
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Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
H Cho et al.
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Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27kip1
JT Barata et al.
BLOOD (2001)
Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene
WS Chen et al.
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Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ)
H Cho et al.
SCIENCE (2001)
Protein kinase B regulates T lymphocyte survival, nuclear factor κB activation, and Bcl-XL levels in vivo
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JOURNAL OF EXPERIMENTAL MEDICINE (2000)
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