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Isabelle Malet et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)
Inhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: Insight into integrase-DNA complex formation and catalysis
Laith Q. Al-Mawsawi et al.
FEBS LETTERS (2008)
The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication
Alan Engelman et al.
PLOS PATHOGENS (2008)
Subunit-specific protein footprinting reveals significant structural Rearrangements and a role for N-terminal Lys-14 of HIV-1 integrase during viral DNA binding
Zhuojun Zhao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Role of PSIP1/LEDGF/p75 in Lentiviral Infectivity and Integration Targeting
Heather M. Marshall et al.
PLOS ONE (2007)
Loop202-208 in avian sarcoma virus integrase mediates tetramer assembly and processing activity
Mary A. Bosserman et al.
BIOCHEMISTRY (2007)
The role of lysine 186 in HIV-1 integrase multimerization
Lionel Berthoux et al.
VIROLOGY (2007)
LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration
Ming-Chieh Shun et al.
GENES & DEVELOPMENT (2007)
Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium
Zvi Hayouka et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Transcriptional coactivator LEDGF/p75 modulates human immunodeficiency virus type 1 integrase-mediated concerted integration
Krishan K. Pandey et al.
JOURNAL OF VIROLOGY (2007)
LEDGF/p75 interferes with the formation of synaptic nucleoprotein complexes that catalyze full-site HIV-1 DNA integration in vitro: Implications for the mechanism of viral cDNA integration
Nidhanapati K. Raghavendra et al.
VIROLOGY (2007)
HIV-1 integrase preassembled on donor DNA is refractory to activity stimulation by LEDGF/p75
Fang Yu et al.
BIOCHEMISTRY (2007)
Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV
Anneleen Hombrouck et al.
PLOS PATHOGENS (2007)
Identification of the LEDGF/p75 binding site in HIV-1 integrase
Katrien Busschots et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
Interactions between HIV-1 Gag molecules in solution: An inositol phosphate-mediated switch
Siddhartha A. K. Datta et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness
Shaila Rahman et al.
VIROLOGY (2007)
LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro
Peter Cherepanov
NUCLEIC ACIDS RESEARCH (2007)
Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication
Jan De Rijck et al.
JOURNAL OF VIROLOGY (2006)
An essential role for LEDGF/p75 in HIV integration
Manuel Llano et al.
SCIENCE (2006)
Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites
Christophe Marchand et al.
NUCLEIC ACIDS RESEARCH (2006)
Relationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity
Elvire Guiot et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75
Manuel Llano et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
Discovery of a small-molecule HIV-1 integrase inhibitor-binding site
Laith Q. Al-Mawsawi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Interactions of HIV-1 Gag with assembly cofactors
N Shkriabai et al.
BIOCHEMISTRY (2006)
Retroviral DNA integration: reaction pathway and critical intermediates
M Li et al.
EMBO JOURNAL (2006)
Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus
L Vandekerckhove et al.
JOURNAL OF VIROLOGY (2006)
Intracytoplasmic maturation of the human immunodeficiency virus type I reverse transcription complexes determines their capacity to integrate into chromatin
Sergey Iordanskiy et al.
RETROVIROLOGY (2006)
A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo
F Turlure et al.
NUCLEIC ACIDS RESEARCH (2006)
Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75
P Cherepanov et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Modulation of replication protein A function by its hyperphosphorylation-induced conformational change involving DNA binding domain B
YY Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication
S Emiliani et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75
P Cherepanov et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)
Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering
M Vanegas et al.
JOURNAL OF CELL SCIENCE (2005)
Mass spectrometric identification of lysines involved in the interaction of human replication protein a with single-stranded DNA
SM Shell et al.
BIOCHEMISTRY (2005)
HIV-1 integrase crosslinked oligomers are active in vitro
A Faure et al.
NUCLEIC ACIDS RESEARCH (2005)
Azido-containing diketo acid derivatives inhibit human immunodeficiency virus type 1 integrase in vivo and influence the frequency of deletions at two-long-terminal-repeat-circle junctions
ES Svarovskaia et al.
JOURNAL OF VIROLOGY (2004)
Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream
MR Arkin et al.
NATURE REVIEWS DRUG DISCOVERY (2004)
Human cell proteins and human immunodeficiency virus DNA integration
F Turlure et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2004)
LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes
M Llano et al.
JOURNAL OF VIROLOGY (2004)
Lens epithelium-derived growth factor/p75 prevents proteasomal degradation of HIV-1 integrase
M Llano et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Class II integrase mutants with changes in putative nuclear localization signals are primarily blocked at a postnuclear entry step of human immunodeficiency virus type 1 replication
R Lu et al.
JOURNAL OF VIROLOGY (2004)
Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase
P Cherepanov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Identification of an inhibitor-binding site to HIV-1 integrase with affinity acetylation and mass spectrometry
N Shkriabai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells
G Maertens et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The barrier-to-autointegration factor is a component of functional human immunodeficiency virus type 1 preintegration complexes
CW Lin et al.
JOURNAL OF VIROLOGY (2003)
Azido-containing aryl β-diketo acid HIV-1 integrase inhibitors
XC Zhang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells
P Cherepanov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Identification of specific HIV-1 reverse transcriptase contacts to the viral RNA:tRNA complex by mass spectrometry and a primary amine selective reagent
M Kvaratskhelia et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein
JY Wang et al.
EMBO JOURNAL (2001)
Role of the non-homologous DNA end joining pathway in the early steps of retroviral infection
L Li et al.
EMBO JOURNAL (2001)
Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain
V Molteni et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2001)
Oligomeric states of the HIV-1 integrase as measured by time-resolved fluorescence anisotropy
E Deprez et al.
BIOCHEMISTRY (2000)
The karyophilic properties of human immunodeficiency virus type 1 integrase are not required for nuclear import of proviral DNA
C Petit et al.
JOURNAL OF VIROLOGY (2000)
Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding
JCH Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Identification of critical amino acid residues in human immunodeficiency virus type 1 IN required for efficient proviral DNA formation at steps prior to integration in dividing and nondividing cells
N Tsurutani et al.
JOURNAL OF VIROLOGY (2000)