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Lawrence G. Iben et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Ex vivo occupancy of γ-secretase inhibitors correlates with brain β-amyloid peptide reduction in Tg2576 mice
Margi E. Goldstein et al.
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Design and synthesis of benzoazepinone-derived cyclic malonamides and aminoamides as potent γ-secretase inhibitors
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Stable isotope labeling tandem mass spectrometry (SILT) to quantify protein production and clearance rates
Randall J. Bateman et al.
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The same γ-secretase accounts for the multiple intramembrane cleavages of APP
Guojun Zhao et al.
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When loss is gain:: reduced presenilin proteolytic function leads to increased Aβ42/Aβ40 -: Talking Point on the role of presenilin mutations in Alzheimer disease
Michael S. Wolfe
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Concentration-dependent modulation of amyloid-β in vivo and in vitro using the γ-secretase inhibitor, LY-450139
Thomas A. Lanz et al.
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Intra- or intercomplex binding to the γ-secretase enzyme
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Presenilin/γ-secretase activity regulates protein clearance from the endocytic recycling compartment
Mei Zhang et al.
FASEB JOURNAL (2006)
Equimolar production of amyloid β-protein and amyloid precursor protein intracellular domain from β-carboxyl-terminal fragment by β-secretase
Nobuto Kakuda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
DAPT-induced intracellular accumulations of longer amyloid β-proteins:: Further implications for the mechanism of intramembrane cleavage by γ-secretase
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BIOCHEMISTRY (2006)
Presenilin clinical mutations can affect γ-secretase activity by different mechanisms
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JOURNAL OF NEUROCHEMISTRY (2006)
Calpain inhibitor MDL28170 modulates Aβ formation by inhibiting the formation of intermediate Aβ46 and protecting Aβ from degradation
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γ-cleavage is dependent on ζ-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain
GJ Zhao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Blocking the cleavage at midportion between γ- and ε-sites remarkably suppresses the generation of amyloid β-protein
T Sato et al.
FEBS LETTERS (2005)
Safety, tolerability, and changes in amyloid β concentrations after administration of a γ-secretase inhibitor in volunteers
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CLINICAL NEUROPHARMACOLOGY (2005)
Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein
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JOURNAL OF NEUROSCIENCE (2005)
Dynamics of β-amyloid reductions in brain, cerebrospinal fluid, and plasma of β-amyloid precursor protein transgenic mice treated with a γ-secretase inhibitor
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JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Longer forms of amyloid β protein:: Implications for the mechanism of intramembrane cleavage by γ-secretase
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JOURNAL OF NEUROSCIENCE (2005)
Identification of a new presenilin-dependent ζ-cleavage site within the transmembrane domain of amyloid precursor protein
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Truncated carboxyl-terminal fragments of β-amyloid precursor protein are processed to amyloid β-proteins 40 and 42
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BIOCHEMISTRY (2004)
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NATURE MEDICINE (2004)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
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SCIENCE (2002)
Cholesterol-dependent γ-secretase activity in buoyant cholesterol-rich membrane microdomains
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NEUROBIOLOGY OF DISEASE (2002)
ELISA analysis of beta-secretase cleavage of the Swedish amyloid precursor protein in the secretory and endocytic pathways
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JOURNAL OF NEUROCHEMISTRY (2002)
Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain
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JOURNAL OF NEUROCHEMISTRY (2001)
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BIOCHEMISTRY (2001)
Presenilin-1 and-2 are molecular targets for γ-secretase inhibitors
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JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1
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NATURE CELL BIOLOGY (2000)
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NATURE CELL BIOLOGY (2000)
Adhesive force of a single gecko foot-hair
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