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Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat a of low density lipoprotein receptor decreases receptor recycling and increases degradation
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Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia
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Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice
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Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice
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The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A-Functional consequences of natural mutations and post-translational modifications
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Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: Lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein receptor
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Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy
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Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
JC Cohen et al.
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Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c
P Costet et al.
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Liver X receptors in cardiovascular and metabolic disease
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Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse
R Essalmani et al.
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Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote
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Severe hypercholesterolemia in four British families with the D374Y mutation in the PCSK9 gene - Long-term follow-up and treatment response
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Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study):: randomised controlled trial
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LANCET (2005)
Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells
F Lalanne et al.
JOURNAL OF LIPID RESEARCH (2005)
Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9
S Rashid et al.
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Effectiveness and tolerability of simvastatin plus fenofibrate for combined hyperlipidemia (The SAFARI Trial)
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AMERICAN JOURNAL OF CARDIOLOGY (2005)
Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment
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Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
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Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia
G Dubuc et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2004)
Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver
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NARC-1/PCSK9 and its natural mutants -: Zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol
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Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype
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Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
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Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice
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Effect of combined fluvastatin-fenofibrate therapy compared with fenofibrate monotherapy in severe primary hypercholesterolemia
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