期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 22, 期 11, 页码 848-852出版社
NATURE RESEARCH
DOI: 10.1038/nsmb.3083
关键词
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资金
- US National Institutes of Health [RCA196884A, HL0795985]
Recent progress has greatly increased the understanding of telomere-bound shelterin proteins and the telomerase holoenzyme, predominantly as separate complexes. Pioneering studies have begun to investigate the requirements for shelterin-telomerase interaction. From this vantage point, focusing on human cells, we review and discuss models for how telomerase and shelterin subunits coordinate to achieve balanced telomere-length homeostasis.
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