期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 283, 期 24, 页码 16693-16701出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M709923200
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资金
- Wellcome Trust [070018, 076114] Funding Source: Medline
We describe here the first characterization of CLEC9A, a group V C-type lectin-like receptor located in the Dectin-1 cluster of related receptors, which are encoded within the natural killer (NK)-gene complex. Expression of human CLEC9A is highly restricted in peripheral blood, being detected only on BDCA3(+) dendritic cells and on a small subset of CD14(+) CD16(-) monocytes. CLEC9A is expressed at the cell surface as a glycosylated dimer and can mediate endocytosis, but not phagocytosis. CLEC9A possesses a cytoplasmic immunoreceptor tyrosine-based activation-like motif that can recruit Syk kinase, and we demonstrate, using receptor chimeras, that this receptor can induce proinflammatory cytokine production. These data indicate that CLEC9A functions as an activation receptor.
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