期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 22, 期 12, 页码 1023-1026出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.3126
关键词
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资金
- Ministry of Science and Technology of China [2013CB910402]
- National Natural Science Foundation of China [31330040, 31270787]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB08010201]
- US National Science Foundation [DGE-1106400]
- US National Institutes of Health [GM54198]
- US Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-06CH11357]
Tetrahymena telomerase holoenzyme subunits p75, p45 and p19 form a subcomplex (7-4-1) peripheral to the catalytic core. We report structures of p45 and p19 and reveal them as the Stn1 and Ten1 subunits of the CST complex, which stimulates telomerase complementary-strand synthesis. 7-4-1 binds telomeric single-stranded DNA, and mutant p19 overexpression causes telomere 3'-overhang elongation. We propose that telomerase-tethered Tetrahymena CST coordinates telomere G-strand and C-strand synthesis.
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