期刊
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
卷 43, 期 4, 页码 425-435出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10863-011-9367-2
关键词
Heat shock proteins; Cytochrome c oxidase; Myocardial ischemia; Mitochondria; ATP-dependent enzyme inhibition
Induction of heat shock proteins (hsp) has been shown to protect cells from ischemia by providing transient tolerance against myocardial injury and improving postischemic functional recovery. Attenuation of ATP depletion and earlier restoration of ATP content on reperfusion are thought to play a role in this scenario. Hsp induction is accompanied by altered enzyme activity of the respiratory chain, the major generator of ATP under physiological conditions. This report addresses the question whether processing and final assembly of the active holoenzyme cytochrome c oxidase (CcO, complex IV), member of the respiratory chain, is compromised under hypoxic conditions unless protected by stress proteins. Special focus is laid on function of the enzyme's subunits and importance of cellular energy availability and maintenance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据