期刊
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
卷 40, 期 5, 页码 521-531出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10863-008-9181-7
关键词
Oxidase; Cytochrome; Proton; Redox; Energy coupling; Pump; Heme; Copper
资金
- National Institutes of Health [HL16101]
- Swedish Research Council
- Knut and Alice Wallenberg Foundation
- Wenner-Gren Foundations
Cytochrome c oxidase generates a proton motive force by two separate mechanisms. The first mechanism is similar to that postulated by Peter Mitchell, and is based on electrons and protons used to generate water coming from opposite sides of the membrane. The second mechanism was not initially anticipated, but is now firmly established as a proton pump. A brief review of the current state of our understanding of the proton pump of cytochrome oxidase is presented. We have come a long way since the initial observation of the pump by Marten Wikstrom in 1977, but a number of essential questions remain to be answered.
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