期刊
JOURNAL OF BIOCHEMISTRY
卷 154, 期 1, 页码 1-10出版社
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvt047
关键词
amino acid; cell growth; stress granule; target of rapamycin; TOR complex
资金
- Japan Society for the Promotion of Science (JSPS) [KAKENHI 23651233]
- Uehara Memorial Foundation
- Salt Science Research Foundation [12D2]
The target of rapamycin (TOR) is an evolutionarily conserved protein kinase that regulates cell growth in response to various environmental as well as intracellular cues through the formation of 2 distinct TOR complexes (TORC), TORC1 and TORC2. Dysregulation of TORC1 and TORC2 activity is closely associated with various diseases, including diabetes, cancer and neurodegenerative disorders. Over the past few years, new regulatory mechanisms of TORC1 and TORC2 activity have been elucidated. Furthermore, recent advances in the study of TOR inhibitors have revealed previously unrecognized cellular functions of TORC1. In this review, we briefly summarize the current understanding of the evolutionarily conserved TOR signalling from upstream regulators to downstream events.
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