期刊
JOURNAL OF BIOCHEMISTRY
卷 153, 期 6, 页码 511-521出版社
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvt035
关键词
ALK; cancer; LRP1; midkine; PTP zeta
资金
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan [23110002]
- MEXT [20390092, 22790311]
- MEXT
- Grants-in-Aid for Scientific Research [23390078] Funding Source: KAKEN
The heparin-binding growth factor midkine (MK) comprises a family with pleiotrophin/heparin-binding growth-associated molecule. The biological phenomena in which MK is involved can be categorized into five areas: (i) cancer, (ii) inflammation/immunity, (iii) blood pressure, (iv) development and (v) tissue protection. The phenotypes are clear in vivo, but the mechanisms by which MK exerts these actions are not fully understood. Candidate receptors for MK include anaplastic lymphoma kinase, protein tyrosine phosphatase zeta, Notch2, LDL receptor-related protein 1, integrins and proteoglycans. Some physical associations between these candidate receptors are also known. Because of the striking in vivo phenotypes after manipulation of MK, MK could be an important molecular target for the treatment of various diseases. To this end, it will be important to pursue studies to fully understand the mechanisms of MK action.
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