期刊
JOURNAL OF BIOCHEMISTRY
卷 151, 期 3, 页码 247-254出版社
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvs004
关键词
BMP; bone; cartilage; transcription factors
资金
- Ministry of Education, Science, Sports and Culture
- The Uehara Memorial Foundation
- The Astellas Foundation for Research on Metabolic Disorders
- Grants-in-Aid for Scientific Research [23792121] Funding Source: KAKEN
Bone morphogenetic protein(s) (BMP) are very powerful cytokines that induce bone and cartilage formation. BMP also stimulate osteoblast and chondrocyte differentiation. During bone and cartilage development, BMP regulates the expression and/or the function of several transcription factors through activation of Smad signalling. Genetic studies revealed that Runx2, Osterix and Sox9, all of which function downstream of BMP, play essential roles in bone and/or cartilage development. In addition, two other transcription factors, Msx2 and Dlx5, which interact with BMP signalling, are involved in bone and cartilage development. The importance of these transcription factors in bone and cartilage development has been supported by biochemical and cell biological studies. Interestingly, BMP is regulated by several negative feedback systems that appear necessary for fine-tuning of bone and cartilage development induced by BMP. Thus, BMP harmoniously regulates bone and cartilage development by forming network with several transcription factors.
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