期刊
JOURNAL OF BIOCHEMISTRY
卷 152, 期 2, 页码 125-131出版社
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvs071
关键词
apelin and APJ; development; regenerative medicine; tumour angiogenesis; vascular formation
资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) [23122511]
- Japan Society for the Promotion of Science (JSPS) [23701054]
- Grants-in-Aid for Scientific Research [22112005, 23701054, 23122511] Funding Source: KAKEN
Apelin is a bioactive peptide with diverse physiological actions on many tissues mediated by its interaction with its specific receptor APJ. Since the identification of apelin and APJ in 1998, pleiotropic roles of the apelin/APJ system have been elucidated in different tissues and organs, including modulation of the cardiovascular system, fluid homeostasis, metabolic pathway and vascular formation. In blood vessels, apelin and APJ expression are spatiotemporally regulated in endothelial cells (ECs) during angiogenesis. In vitro analysis revealed that the apelin/APJ system regulates angiogenesis by the induction of proliferation, migration and cord formation of cultured ECs. Moreover, apelin seems to stabilize cell-cell junctions of ECs. In addition, genetically engineered mouse models suggest that apelin/APJ regulates vascular stabilization and maturation in physiological and pathological angiogenesis. In this review, we summarize the current understanding of the apelin/APJ system for vascular formation and maturation.
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